What question did this study set out to answer?

To develop a new synthetic method for 2-amino and 2-thio-substituted quinolines.

April 29, 2026

Base- Mediated 2+4 Annulation of Benzothiazolium Salts and 2-Aminobenzaldehydes: Selective Synthesis of 2-Amino and 2-Thio- Substituted Quinolines

Key Points

To develop a new synthetic method for 2-amino and 2-thio-substituted quinolines.
Transition-metal-free [2+4] cyclization of benzothiazolium salts with 2-aminobenzaldehydes.
Control of chemoselectivity during the reaction.
Successfully synthesized N-substituted and S-substituted quinoline derivatives.
Demonstrated significance in chemoselectivity for quinoline formation.

Abstract

A transition-metal-free 2+4 cyclization reaction of benzothiazolium salts with 2-aminobenzaldehydes has been developed, enabling the selective synthesis of N-substituted and S-substituted quinoline derivatives. The chemoselectivity is primarily controlled by the...

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