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This research focuses on developing a novel imaging probe for detecting peroxynitrite in living organisms.

May 6, 2026

Engineering Coumarin‐Based Afterglow Luminescence Probes for Activatable Imaging Peroxynitrite In Vivo

Key Points

This research focuses on developing a novel imaging probe for detecting peroxynitrite in living organisms.
Engineered coumarin-based luminescence probes
Induction of afterglow emission through singlet oxygen production
Evaluation of imaging capabilities in ulcerative colitis and Parkinson's disease models.
The probes exhibited high activation contrast and reduced autofluorescence
Demonstrated efficacy in assessing therapeutic responses in both ulcerative colitis and Parkinson's disease.

Abstract

primes the probe, whereas subsequent irradiation induces coumarin-mediated singlet oxygen generation that reacts with the methylenecyclobutane unit to initiate afterglow emission. By virtue of the elimination of autofluorescence and high activation contrast, C545-MP NPs enable precise assessing therapeutic efficacy of ulcerative colitis and Parkinson's disease.

Engineering Coumarin‐Based Afterglow Luminescence Probes for Activatable Imaging Peroxynitrite In Vivo

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Abstract

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