TEMPO-Promoted Thioacid-Amine Coupling for Peptide Synthesis

Key Points

• To introduce a mild and epimerization-free strategy for peptide synthesis using TEMPO.
• Developed a protocol for peptide bond formation using TEMPO to promote oxidative coupling.
• Utilized thiocarboxylic acids and amines as key reactants.
• Ensured the reaction conditions minimized epimerization.
• Successfully achieved peptide bond formation in a mild manner.
• Demonstrated the effectiveness of oxidative coupling without epimerization.
• Presented a novel approach with selective oxidation of thiocarboxylic acids.