231 Mapping the National Center for Advancing Translation Sciences (NCATS) translational science principles to Clinical and Translational Science Awards (CTSA) UM1 hub initiatives

Objectives/Goals: Apply the NCATS translational science principles as a framework to describe CTSA UM1 hub activities in terms of effective translational science approaches. Identify and characterize the distribution of principles across UM1-funded initiatives to support strategic management and reporting. Methods/Study Population: Hub-affiliated faculty and staff convened at an annual, in-person retreat for the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. Module teams, including at least one co-lead from Workforce Development for Clinical Research Staff Professionals (C1), Community and Partner Engaged Research (C2), Resources and Services (D1), and Health Informatics (D3), completed a concept mapping exercise to identify which, if any, of the 7 translational science principles were exemplified by their initiatives. Teams worked collaboratively to map principles to each initiative. Data were aggregated at the module and hub levels. Results/Anticipated Results: Each module reported 5–10 active, UM1-funded initiatives. Every initiative was mapped to>2 translational science principles, with 2 initiatives mapped to all 7 principles. On average, 4.6 principles were identified per initiative. “Focus on Unmet Needs” was the most highly reported across all initiatives. “Boundary-Crossing Partnerships,” mapped to all Community and Partner Engaged Research (C2) projects, and “Creativity and Innovation” mapped to all resources and services (D1). 90% of Informatics (D3) initiatives were mapped to “Generalizable Solutions.” Across the hub, “Bold and Rigorous Approaches” was the least likely to be identified. Discussion/Significance of Impact: The translational science principles can be used to frame module-specific and hub-wide strengths and gaps. Concept mapping can be incorporated into project planning and reporting to increase shared understanding and alignment with the principles that support the translational science enterprise.