Outside Front Cover: A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Key Points

• This research aims to develop effective inhibitors targeting UDP-galactose-4-epimerase to modulate its activity.
• Employs a synergistic fragment screening strategy to identify covalent and non-covalent inhibitors.
• Utilizes high-resolution crystallography to analyze enzyme-inhibitor complexes.
• Successfully developed both covalent and non-covalent inhibitors against UDP-galactose-4-epimerase.
• High-resolution structures of enzyme-inhibitor complexes provide insights into binding mechanisms.