Research Article reports the development of inhibitors for UDP-galactose-4-epimerase, indicating significant therapeutic potential.
The enzyme UDP-galactose-4-epimerase (GalE) is crucial for the cellular biosynthesis of nucleotide-sugars. In the Research Article e20304, Benjamin Schumann and co-workers use a synergistic fragment screening strategy to develop both covalent and non-covalent inhibitors against GalE. The work is underpinned by high-resolution crystallography of enzyme-inhibitor complexes. Image by Dr Stephane Mouilleron.
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Browne et al. (2026) studied this question.
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