Mechanistic study on the role of NCSTN in regulating the differentiation of airway epithelial basal cells into ciliated cells following CSE exposure

Key Points

• This study aims to explore how NCSTN regulates the differentiation of airway epithelial basal cells into ciliated cells after CSE exposure.
• Investigated the effects of inhibiting the NCSTN-Notch3-Hes1 pathway.
• Assessed ciliated cell differentiation following CSE exposure.
• Inhibition of the NCSTN-Notch3-Hes1 pathway significantly promoted ciliated cell differentiation.
• Amelioration of CSE-induced reduction in ciliated cells was observed.