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May 9, 2026Experimental Lung ResearchOpen Access

Mechanistic study on the role of NCSTN in regulating the differentiation of airway epithelial basal cells into ciliated cells following CSE exposure

Maohua Lan Caimei Wang Yanhui Gu Zhiquan He Zhenglu Li Yi Lan Nan Liu Jinyang Hu Guocheng Yuan

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Key Points

This study aims to explore how NCSTN regulates the differentiation of airway epithelial basal cells into ciliated cells after CSE exposure.
Investigated the effects of inhibiting the NCSTN-Notch3-Hes1 pathway.
Assessed ciliated cell differentiation following CSE exposure.
Inhibition of the NCSTN-Notch3-Hes1 pathway significantly promoted ciliated cell differentiation.
Amelioration of CSE-induced reduction in ciliated cells was observed.

Implication

Mechanistic study reveals NCSTN inhibition enhances differentiation into ciliated cells following CSE exposure.

Abstract

Inhibition of the NCSTN-Notch3-Hes1 pathway promoted ciliated cell differentiation and ameliorated the CSE-induced reduction in ciliated cells.

Discussion

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Cite This Study

Lan et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2fdce8c8c81e96404e8 https://doi.org/10.1080/01902148.2026.2664336

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Reversal of cigarette smoke extract‐induced sinonasal epithelial cell barrier dysfunction through Nrf2 ActivationOriginal Research · 2016 · 40 citations
2Caveolin-1 modulates Notch transcriptional activity during in vitro respiratory multiciliated cell maturationOriginal Research · 2026
3Inhibition of Airway Epithelial CTSC Attenuates Type 2 Inflammation: Implications for Eosinophilic Chronic Rhinosinusitis with Nasal PolypsOriginal Research · 2026
4Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lungOriginal Research · 2026
5Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lungOriginal Research · 2025 · 1 citations

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