What question did this study set out to answer?

This series aims to explore the rare occurrence of dural progression in glioblastoma and its implications.

May 12, 2026Radiology Case Reports0 citationsOpen Access

High-grade glioma with dural progression: A single-center case series and review of literature

GWGeorge WangUniversity of Southern California ANAbraham NirappelCase Western Reserve University AKArashdeep KaurUniversity Hospitals of Cleveland

Key Points

This series aims to explore the rare occurrence of dural progression in glioblastoma and its implications.
Presented 4 cases of glioblastoma with dural-based progression from a single-center case series.
Reviewed relevant literature to analyze imaging characteristics and potential pathophysiology.
Examined diagnostic and management strategies for this rare manifestation.
Identified unique MRI imaging features indicative of dural involvement.
Explored potential mechanisms driving dural progression in glioblastoma.
Discussed management options that could improve outcomes for affected patients.

Abstract

Glioblastoma is the most common and aggressive primary brain tumor in adults. However, despite its aggressive nature, dural-based progression remains exceedingly rare. This rarity is partially due to the protective effects of the blood-brain barrier and the poor survival of affected patients. As a result, the pathophysiology and imaging characteristics of dural-based glioblastoma progression remain poorly understood and underreported. In this case series, we present 4 cases of glioblastoma with dural-based progression and review the relevant literature. We highlight the MRI imaging features of dural progression and explore potential pathophysiology, diagnosis, and management in this rare manifestation.

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