April 13, 2004Open Access
Race-Specific Relationships Between Coronary and Carotid Artery Calcification and Carotid Intimal Medial Thickness
Key Result
Calcified plaque in the coronary and carotid arteries was positively associated with carotid intimal medial thickness (r=0.36 and r=0.45, respectively; both P<0.0001).
Study Design
Type
Cross-Sectional (n=438)
PICO
Population
Subclinical atherosclerosis (n=438)
Intervention / Comparator
Coronary and carotid artery calcification vs Carotid intimal medial thickness (IMT)
Primary Outcome
Correlation between calcified arterial plaque and carotid IMT — r=0.36 (coronary), r=0.45 (carotid), p=<0.0001
Main Result
Effect estimate: r=0.36 (coronary), r=0.45 (carotid)
p-value: p=<0.0001
Abstract
BACKGROUND AND PURPOSE: Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT). METHODS: Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants. RESULTS: Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes. CONCLUSIONS: Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.
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Authors
Lynne E. Wagenknecht
Preventive Cardiology
C
Carl D. Langefeld
Broad Institute
J
J. Jeffrey Carr
American College of Radiology
Journals
Stroke
Actions
Institutions
Wake Forest University
References and Citations
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