Iodine-Mediated Multicomponent Deaminative Cyclization for Direct Transformation of Inert Amides into Aromatic Lactones

Key Points

• The aim is to develop a method for directly converting inert amides into aromatic lactones using a multicomponent approach.
• Utilized iodine-mediated deaminative cyclization to facilitate the reaction.
• Assembled α-pyrone aromatic lactones involving amides with active methylene groups.
• Created a framework that allows the functionalization of inert amides.
• Successfully transformed inert amides into aromatic lactones.
• Overcame limitations of traditional methods that produce only linear esters.
• Established a new platform for synthesizing complex heterocycles.