Multicomponent framework transforms inert amides into aromatic lactones, indicating new functionalization avenues.
)-one, and amides containing an active methylene group to efficiently assemble structurally unique α-pyrone aromatic lactones. Notably, this work achieves the direct transformation of amides into aromatic lactones within a multicomponent framework, overcoming the traditional limitation of forming only linear esters, and establishes a new platform for inert amide functionalization and complex heterocycle synthesis.
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Ma et al. (2026) studied this question.
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