Butyrate Alleviates Hyperuricemia by Selectively Targeting the Metronidazole/Neomycin-Sensitive Bacterium Dubosiella newyorkensis

Key Points

• The study aims to explore how butyrate and the bacterium Dubosiella newyorkensis affect hyperuricemia.
• Molecular analyses measured the expression of URAT1 and ABCG2.
• Histopathological evaluations assessed glomerular function and tissue damage due to hyperuricemia.
• Interventions focused on promoting uric acid excretion through microbiome modulation.
• Dn significantly downregulated URAT1 expression, enhancing uric acid excretion.
• ABCG2 expression was upregulated, further supporting uric acid elimination.
• Histopathological assessments indicated restoration of kidney structures affected by hyperuricemia.