Butyrate Alleviates Hyperuricemia by Selectively Targeting the Metronidazole/Neomycin-Sensitive Bacterium Dubosiella newyorkensis

Xinyu Cheng; Yifan Lei; Shuyang Zhang; Liping Chen; Yongzhong Wang

doi:10.1021/acs.jafc.5c13934

May 13, 2026Journal of Agricultural and Food Chemistry

Butyrate Alleviates Hyperuricemia by Selectively Targeting the Metronidazole/Neomycin-Sensitive Bacterium Dubosiella newyorkensis

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Key Points

The study aims to explore how butyrate and the bacterium Dubosiella newyorkensis affect hyperuricemia.
Molecular analyses measured the expression of URAT1 and ABCG2.
Histopathological evaluations assessed glomerular function and tissue damage due to hyperuricemia.
Interventions focused on promoting uric acid excretion through microbiome modulation.
Dn significantly downregulated URAT1 expression, enhancing uric acid excretion.
ABCG2 expression was upregulated, further supporting uric acid elimination.
Histopathological assessments indicated restoration of kidney structures affected by hyperuricemia.

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Implication

Shows butyrate alleviates hyperuricemia by targeting Dubosiella newyorkensis, suggesting new therapy avenues.

Abstract

, thereby enhancing the production of acetate, propionate, and butyrate. Molecular analyses demonstrated that Dn downregulated the expression of URAT1 while upregulating ABCG2, thereby promoting UA excretion. Histopathological evaluation confirmed that Dn restored the glomerular atrophy, tubular dilation, and collagen deposition induced by HUA. These findings suggest that Dn is a promising multitarget therapeutic agent for HUA and provides a scientific foundation for the development of novel microbiome-based strategies against HUA.

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Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a080a71a487c87a6a40c5da https://doi.org/10.1021/acs.jafc.5c13934

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Butyrate Alleviates Hyperuricemia by Selectively Targeting the Metronidazole/Neomycin-Sensitive Bacterium Dubosiella newyorkensis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Butyrate Alleviates Hyperuricemia by Selectively Targeting the Metronidazole/Neomycin-Sensitive Bacterium Dubosiella newyorkensis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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