The ETiCS study is designed to prospectively assess the etiology, titre-course, and effect on survival of beta1-adrenoceptor autoantibodies in patients with human heart disease.
Observational
Yes
Do acute myocarditis or myocardial infarction trigger autoimmune reactions leading to the generation of cardiac beta1-adrenoceptor autoantibodies?
The ETiCS study is a large clinical diagnostic study designed to investigate the pathophysiology, prevalence, and prognostic significance of cardiac beta1-adrenoceptor autoantibodies in patients with heart disease.
AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy. METHODS: We recently developed a novel highly sensitive fluorescence-based functional assay to detect stimulating beta1-aabs. We will use this method to assess Etiology, Titre-Course, and effect on Survival (ETiCS) of beta1-aabs in a prospective multicentre study with serial follow-up of patients after a first acute myocarditis or myocardial infarction. Several European core laboratories will jointly study the hypothesis that both disorders may trigger autoimmune reactions leading to the generation of beta1-aabs and/or other heart-directed aabs. Further, sera from healthy controls and well-characterized patient cohorts with dilated, ischaemic, or hypertensive cardiomyopathy will be analysed retrospectively for beta1-aab prevalence, incidence, persistence, and/or clearance. CONCLUSION: ETiCS is so far the largest clinical diagnostic study projected to address cardiac autoimmunity. It attempts to unravel the pathophysiology of cardiac autoantibody formation and persistence/clearance. ETiCS will enhance current knowledge on autoimmunity in human heart disease and promote endeavours to develop novel therapies targeting cardiac aabs.
Deubner et al. (Fri,) conducted a observational in Acute myocarditis, myocardial infarction, and cardiomyopathy. Fluorescence-based functional assay for beta1-aabs was evaluated on Etiology, titre-course, and effect on survival of beta1-aabs; prevalence, incidence, persistence, and clearance. The ETiCS study is designed to prospectively assess the etiology, titre-course, and effect on survival of beta1-adrenoceptor autoantibodies in patients with human heart disease.