Key points are not available for this paper at this time.
A method for the quantitative assessment of rapid changes in the delivery rate of hormones into the systemic circulation is reported. Plasma hormone levels are examined in relation to the “non-steady-state” disappearance rate measured following an intravenous infusion of the hormone. The insulin delivery rate in response to iv glucose has been measured; a biphasic insulin response has been confirmed; and the amount of insulin entering the systemic circulation in each phase can be examined.
Turner et al. (Sun,) studied this question.