What does this research mean for the field?

Newly synthesized mono- and bis-isoxazoline compounds demonstrate strong antibacterial activity and exhibit stable target binding in key pharmacological pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to synthesize and evaluate novel mono- and bis-isoxazolines for their antibacterial properties.

May 20, 2026RSC Advances2 citationsOpen Access

Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

AAAli AltharawiPrince Sattam Bin Abdulaziz University BCBharath Kumar ChagaletiSRM Institute of Science and Technology MAMubarak A. AlamriPrince Sattam Bin Abdulaziz University

Key Points

This research aims to synthesize and evaluate novel mono- and bis-isoxazolines for their antibacterial properties.
Synthesis of new mono- and bis-isoxazolines compounds.
Evaluation of antibacterial activity through in vitro testing.
Utilization of molecular modeling techniques, including docking and molecular dynamics, to analyze binding stability.
Novel isoxazolines exhibited strong antibacterial activity against selected strains.
Molecular modeling confirmed stable binding interactions with targeted pathways.
Network pharmacology identified key pathways modulated by the compounds.

Abstract

Novel mono- and bis-isoxazoline compounds were synthesized and showed strong antibacterial activity. Network pharmacology highlights key pathways involved, and supported by docking and molecular dynamics, confirming stable target binding.

KI fragen

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