Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

Q: What does this research mean for the field?

Newly synthesized mono- and bis-isoxazoline compounds demonstrate strong antibacterial activity and exhibit stable target binding in key pharmacological pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ali Altharawi; Bharath Kumar Chagaleti; Mubarak A. Alamri; Yassine Riadi; Taibah Aldakhil; Ait Itto Moulay Youssef; Ali Oubella; Reda A. Haggam

doi:10.1039/d5ra09902a

January 1, 2026RSC AdvancesOpen Access

Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to synthesize and evaluate novel mono- and bis-isoxazolines for their antibacterial properties.
Synthesis of new mono- and bis-isoxazolines compounds.
Evaluation of antibacterial activity through in vitro testing.
Utilization of molecular modeling techniques, including docking and molecular dynamics, to analyze binding stability.
Novel isoxazolines exhibited strong antibacterial activity against selected strains.
Molecular modeling confirmed stable binding interactions with targeted pathways.
Network pharmacology identified key pathways modulated by the compounds.

Implication

Evaluates antibacterial activity of new isoxazoline compounds, suggesting promising pathways for treatment.

Abstract

Novel mono- and bis-isoxazoline compounds were synthesized and showed strong antibacterial activity. Network pharmacology highlights key pathways involved, and supported by docking and molecular dynamics, confirming stable target binding.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Altharawi et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5100f03e14405aa9d3ed https://doi.org/10.1039/d5ra09902a

View Full Paper

Ask AI

Bookmark

Share

Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading