What question did this study set out to answer?

This research aims to synthesize and evaluate novel isoxazole-based heterocyclic hybrids for their bioactivity.

March 13, 2026RSC Advances3 citationsOpen Access

New isoxazole-based heterocyclic hybrids with dual antimicrobial and antioxidant bioactivity: integrated synthesis, in vitro assessment, and computational exploration

AAAziz ArzineSidi Mohamed Ben Abdellah University SASoumia Ait AssouSidi Mohamed Ben Abdellah University LBLamiae El BouamriUniversity of Hassan II Casablanca

Key Points

This research aims to synthesize and evaluate novel isoxazole-based heterocyclic hybrids for their bioactivity.
Synthesis of novel isoxazole-based heterocyclic compounds
Characterization of compounds for quality assessment
Evaluation of antimicrobial properties using in vitro techniques
Assessment of antioxidant activities through in vitro assays
Computational exploration to support findings
New compounds exhibited significant antimicrobial activity against various pathogens
Antioxidant activity was confirmed through established assay methods
In silico analysis indicated favorable interactions at the molecular level

Abstract

This article reports comprehensive research on the synthesis of novel isoxazole-based heterocyclic hybrids, their characterization and the evaluation of their antimicrobial and antioxidant properties, employing both in vitro and in silico approaches.

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