Computed tomography imaging correlated with gross infarct weight (r=0.83) in isolated canine hearts, although it consistently underestimated infarct volume.
Does computed tomography accurately localize and size experimental acute myocardial infarcts compared to gross pathology in a canine model?
CT imaging demonstrates strong correlation with gross pathology for sizing acute myocardial infarcts in an experimental model, highlighting its potential for clinical evaluation.
Effect estimate: r=0.83
Computed tomography (CT) has been used to quantitate acute myocardial infarct size in isolated, arrested canine hearts. Acute myocardial infarcts were produced in 20 hearts by either left anterior descending (13 dogs) or circumflex coronary artery ligation (seven dogs). Each animal was given iodinated contrast media intravenously immediately before sacrifice 24--72 hours postinfarction. All infarcts greater than 1 g and one of three infarcts 0.5 g or less were detected by CT imaging. Infarct volume determined by CT correlated with gross infarct weight (r=0.83). CT imaging, however, consistently underestimated infarct volume; underestimation was largest in a group of patchy, predominantly subendocardial infarcts. As adequate equipment and techniques for in vivo studies are developed, CT imaging of the heart may become important in clinical evaluation of myocardial infarction.
Gray et al. (Fri,) conducted a other in Acute myocardial infarction (n=20). Computed tomography (CT) imaging vs. Gross infarct weight was evaluated on Correlation of infarct volume determined by CT with gross infarct weight (r=0.83). Computed tomography imaging correlated with gross infarct weight (r=0.83) in isolated canine hearts, although it consistently underestimated infarct volume.