Young patients with established Type 1 diabetes had significantly greater carotid intima-media thickness (0.57 mm) than healthy controls (0.52 mm) and recently diagnosed patients (0.50 mm, p<0.001).
Cross-Sectional (n=390)
Is established Type 1 diabetes mellitus associated with increased carotid intima-media thickness in young patients compared to healthy controls or recently diagnosed patients?
Young patients with established Type 1 diabetes exhibit increased carotid intima-media thickness, an early marker of atherosclerosis, which is strongly associated with the presence of diabetic nephropathy.
Absolute Event Rate: 0.57% vs 0.52%
p-value: p=<0.001
To investigate associations between early atherosclerosis and possible risk factors for it in young patients with established Type 1 diabetes mellitus (DM), we measured the combined intima-media thickness (IMT) of the common carotid arteries with high resolution ultrasound in 310 young patients (age or = 2 years, and in two control groups of similar age (control 1:40 healthy subjects, control 2: 40 Type 1 DM recently diagnosed patients). Albumin excretion rate and lipids (total cholesterol and triglycerides) were measured and retinopathy and hypertension (systolic blood pressure > 140 or diastolic blood pressure > 90 mmHg) sought in the patients. Mean maximum IMT was 0.52 +/- 0.06 mm in control group 1 and 0.50 +/- 0.05 mm in control group 2 with a mean difference of 0.02 mm (95% CI: -0.01, 0.04). The more established Type 1 DM patients had a significantly greater IMT (0.57 +/- 0.13 mm, p < 0.001) than both control groups. In a subgroup analysis, patients with microvascular diabetic complications (n = 99) had a significantly greater IMT (0.63 +/- 0.17 vs 0.55 +/- 0.10 mm, p < 0.001) than those without (n = 211). In a multiple linear regression analysis with a significance level of < or = 0.10, the carotid artery IMT of our established diabetic patients was related to age, male gender, triglycerides and nephropathy, suggesting the latter as the main diabetes-specific risk for intima-media thickening in young Type 1 DM patients.
Frost et al. (Thu,) conducted a cross-sectional in Type 1 diabetes mellitus (n=390). Established Type 1 diabetes mellitus vs. Healthy subjects and recently diagnosed Type 1 DM patients was evaluated on Combined intima-media thickness (IMT) of the common carotid arteries (p=<0.001). Young patients with established Type 1 diabetes had significantly greater carotid intima-media thickness (0.57 mm) than healthy controls (0.52 mm) and recently diagnosed patients (0.50 mm, p<0.001).