Does x-irradiation alter vascularity and blood flow in Walker carcinoma 256 of rats?
X-irradiation of Walker carcinoma 256 in rats leads to decreased functional intravascular volume and altered blood flow dynamics, possibly due to arteriovenous shunting.
Changes in functional intravascular volume, extravasation of plasma protein, and blood flow were measured with radioisotopes in Walker carcinoma 256 of rats after 2,000 rads of x irradiation in a single exposure. The functional intravascular volume significantly decreased during the 1–11 day postirradiation period. The extravasation rate of circulating 125I-labeled plasma protein markedly increased soon after irradiation, then abruptly declined. Clearance of interstitially deposited 133Xe increased significantly 6 days after irradiation, possibly because of rapid blood flow through newly-formed arteriovenous shunts due to occlusion and stasis in the networks of long capillaries.
Song et al. (Fri,) studied this question.