Why the study?
Does x-irradiation alter vascularity and blood flow in Walker carcinoma 256 of rats?
Does x-irradiation alter vascularity and blood flow in Walker carcinoma 256 of rats?
X-irradiation of Walker carcinoma 256 in rats leads to decreased functional intravascular volume and altered blood flow dynamics, possibly due to arteriovenous shunting.
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Radiation effects on tumor vascularity in this rat model should not guide clinical practice; leaves open mechanisms of altered perfusion post-irradiation.
Changes in functional intravascular volume, extravasation of plasma protein, and blood flow were measured with radioisotopes in Walker carcinoma 256 of rats after 2,000 rads of x irradiation in a single exposure. The functional intravascular volume significantly decreased during the 1–11 day postirradiation period. The extravasation rate of circulating 125I-labeled plasma protein markedly increased soon after irradiation, then abruptly declined. Clearance of interstitially deposited 133Xe increased significantly 6 days after irradiation, possibly because of rapid blood flow through newly-formed arteriovenous shunts due to occlusion and stasis in the networks of long capillaries.
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Song et al. (1972) studied this question.
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