Key result
Single exposure to 3,000 and 6,000 R of x-rays decreased vascular volume in Walker 256 rat tumors, whereas it increased vascular volume in normal skin and muscle.
Population
Rats with Walker 256 tumors
Design
Preclinical
Authors
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May differentially affect tumor versus normal tissue vasculature in rats; leaves open translation to human radiotherapy.
X-ray irradiation decreases vascular volume in experimental tumors while increasing it in normal tissues like skin and muscle.
Song et al. (1970) studied this question. Single exposure to 3,000 and 6,000 R of x-rays decreased vascular volume in Walker 256 rat tumors, whereas it increased vascular volume in normal skin and muscle.
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