Key result
X-irradiation reduces large vessel blood conduction efficiency in mice, sometimes causing severe ischemia and necrosis.
Why the study?
Does 2000 r of x-rays reduce the efficiency of the vascular system in the hind limbs of mice?
Population
3-week- and 12-week-old mice
Design
Preclinical
Follow-up
13 weeks to 87 weeks
Authors
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May signal late vascular risks after high-dose irradiation; leaves open translation to human radiotherapy.
Does 2000 r of x-rays reduce the efficiency of the vascular system in the hind limbs of mice?
High-dose X-irradiation to the mouse hind limb causes long-term vascular impairment, ischemia, and necrosis, likely driven by radiation-induced fibrosis and intimal proliferation.
Alice Sams (1963) studied Radiation-induced vascular impairment. X-irradiation was evaluated on Efficiency of larger irradiated vessels in conducting blood. X-irradiation of 2000 r to the hind limbs of mice reduced the efficiency of larger vessels in conducting blood between 13 and 87 weeks post-irradiation, sometimes causing severe ischaemia and necrosis.
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