A risk calculation model incorporating lncRNA gene loci, sex, age, and BMI predicted the development of type 2 diabetes mellitus with an AUC of 95.30% (95% CI 93.50-97.40).
Case-Control (n=1,010)
Are polymorphic variants of long non-coding RNA genes associated with the development of type 2 diabetes mellitus?
Specific long non-coding RNA gene polymorphisms are associated with type 2 diabetes mellitus and related metabolic or cardiovascular traits, and can be used in a predictive risk model.
Effect estimate: AUC 95.30% (95% CI 93.50-97.40)
Type 2 diabetes mellitus (T2DM) is a disease characterized by increased blood glucose, formed as a result of impaired mechanisms of insulin binding to cells. DNA samples of patients with T2DM (N = 535) and healthy individuals (N = 475) were used. We identified the association of lncRNA gene loci LINC02227 rs2149954 (OR = 0.76, P = 0.0083, PFDR = 0.017), LINC00305 rs2850711 (OR = 1.43, P = 0.0017, PFDR = 0.004) and CDKN2B-AS1 rs4977574 (OR = 0.70, P = 0.0001, PFDR = 0.0003) in an additive model with T2DM. The LINC00305 gene locus rs2850711 showed association with fasting glucose level (P = 0.023), C-peptide level (P = 0.00001), LINC02227 rs2149954 and CDKN2B-AS1 rs4977574 loci showed association with hypertension. MALAT rs619586 gene polymorphism was associated with C-peptide (P = 0.017), LDL (P = 0.012) and total cholesterol levels (P = 0.01). CDKN2B-AS1 rs4977574 gene polymorphism showed association with C-peptide levels (P = 0.027). SNP LINC02227 rs2149954 was associated with obesity (P = 0.0011, PFDR = 0.008). MEG3 rs7158663 gene polymorphism was associated with post infarct cardiosclerosis (P = 0.02). ROC curve analysis showed that the studied loci and variables such as sex, age of subjects and BMI level, included in the construction of the risk calculation model, could predict the development of T2DM with a sensitivity of 98.0% and specificity of 97.0%, the area under the AUC curve was 95.30% (95%CI 93.50–97.40).
Кочетова et al. (Tue,) conducted a case-control in Type 2 diabetes mellitus (n=1,010). lncRNA gene loci variants (LINC02227, LINC00305, CDKN2B-AS1) vs. Healthy individuals was evaluated on Prediction of T2DM development using a risk calculation model (AUC 95.30%, 95% CI 93.50-97.40). A risk calculation model incorporating lncRNA gene loci, sex, age, and BMI predicted the development of type 2 diabetes mellitus with an AUC of 95.30% (95% CI 93.50-97.40).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: