Key result
Risk model incorporating lncRNA loci, sex, age, and BMI predicts T2DM with ~95% AUC.
Why the study?
Are polymorphic variants of long non-coding RNA genes associated with the development of type 2 diabetes mellitus?
Population
535 patients with T2DM and 475 healthy individuals
Comparison
Polymorphic variants of lncRNA genes in T2DM vs healthy individuals
Authors
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May aid T2DM risk models in research; leaves open prospective validation before clinical use.
Case-Control (n=1,010)
Are polymorphic variants of long non-coding RNA genes associated with the development of type 2 diabetes mellitus?
Effect estimate: AUC 95.30% (95% CI 93.50-97.40)
Specific long non-coding RNA gene polymorphisms are associated with type 2 diabetes mellitus and related metabolic or cardiovascular traits, and can be used in a predictive risk model.
Кочетова et al. (2024) conducted a case-control in Type 2 diabetes mellitus (n=1,010). lncRNA gene loci variants (LINC02227, LINC00305, CDKN2B-AS1) vs. Healthy individuals was evaluated on Prediction of T2DM development using a risk calculation model (AUC 95.30%, 95% CI 93.50-97.40). A risk calculation model incorporating lncRNA gene loci, sex, age, and BMI predicted the development of type 2 diabetes mellitus with an AUC of 95.30% (95% CI 93.50-97.40).
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