Key result
The C/C genotype of rs6769511 in IGF2BP2 was significantly associated with an increased risk of developing type 2 diabetes mellitus compared to the T/T-C/T genotype (OR 1.76).
Why the study?
Lipid metabolism and related genetic factors lead to insulin resistance, making it meaningful to investigate associations between single-nucleotide polymorphisms in lipid metabolism-related genes and T2DM.
Are single-nucleotide polymorphisms in lipid metabolism-related genes associated with type 2 diabetes mellitus in a Chinese population?
Case-Control (n=2,468)
No
Are single-nucleotide polymorphisms in lipid metabolism-related genes associated with type 2 diabetes mellitus in a Chinese population?
Odds Ratio: 1.76 (95% CI 1.29–2.42)
p-value: p=<0.001
The rs6769511 polymorphism and specific haplotypes in the IGF2BP2 gene are significantly associated with an increased risk of type 2 diabetes mellitus in a Chinese Han population.
SNP associations with T2DM are hypothesis-generating; leaves open causal or predictive roles pending replication.
Background: Type 2 diabetes mellitus (T2DM) is a complex chronic metabolic disorder triggered by insulin resistance in peripheral tissues. Evidence has shown that lipid metabolism and related genetic factors lead to insulin resistance. Hence, it is meaningful to investigate the association between single-nucleotide polymorphisms (SNPs) in lipid metabolism-related genes and T2DM. Methods: A total of 1,194 subjects with T2DM and 1,274 Non-diabetic subjects (NDM) were enrolled. Five SNPs in three genes (rs864745 in JAZF1, rs35767 in IGF1, and rs4376068, rs4402960, and rs6769511 in IGF2BP2) that contribute to insulin resistance involving lipid metabolism were genotyped using the MassArray method in a Chinese population. Results: The allele and genotypes of rs6769511 in IGF2BP2 were associated with T2DM (P=0.009 and P=0.002, respectively). In inheritance model analysis, compared with the T/T-C/T genotype, the C/C genotype of rs6769511 in IGF2BP2 was a risk factor for the development of T2DM (P<0.001, odds ratio [OR] =1.76; 95% confidence interval [CI]: 1.29-2.42). Haplotype analysis revealed associations of the rs4376068-rs4402960-rs6769511 haplotypes in IGF2BP2 with the development of T2DM (P=0.015). Additionally, rs4376068C-rs4402960T-rs6769511C was a risk haplotype for T2DM (OR=1.179; 95% CI: 1.033-1.346).
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Li et al. (2020) conducted a case-control in Type 2 diabetes mellitus (n=2,468). rs6769511 C/C genotype in IGF2BP2 vs. T/T-C/T genotype was evaluated on Development of Type 2 diabetes mellitus (OR 1.76, 95% CI 1.29-2.42, p=<0.001). The C/C genotype of rs6769511 in IGF2BP2 was significantly associated with an increased risk of developing type 2 diabetes mellitus compared to the T/T-C/T genotype (OR 1.76).
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