Key result
Specific lncRNA variants are linked to ~43% higher T2DM risk and enable highly predictive models.
Why the study?
Are polymorphic variants of lncRNA genes associated with the development of Type 2 Diabetes Mellitus?
Population
535 patients with T2DM and 475 healthy individuals
Comparison
Patients with T2DM vs healthy individuals
Authors
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LncRNA variants were associated with T2DM; leaves open validation of prediction models in prospective cohorts before any clinical use.
Case-Control (n=1,010)
Are polymorphic variants of lncRNA genes associated with the development of Type 2 Diabetes Mellitus?
Effect estimate: OR 1.43
p-value: p=0.0017
Polymorphic variants of specific lncRNA genes are associated with T2DM and related metabolic traits, and a risk model including these loci, sex, age, and BMI can predict T2DM development with high sensitivity and specificity.
Кочетова et al. (2024) conducted a case-control in Type 2 diabetes mellitus (n=1,010). lncRNA gene loci polymorphisms (LINC02227, LINC00305, CDKN2B-AS1) vs. Healthy individuals was evaluated on Association with T2DM (LINC00305 rs2850711) (OR 1.43, p=0.0017). Polymorphic variants of lncRNA genes LINC02227, LINC00305, and CDKN2B-AS1 were significantly associated with T2DM, and a risk model including these loci predicted T2DM with an AUC of 95.30%.
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