The new simple formula LDL-c = 3/4 (TC - HDL-c) provided a higher correlation with directly measured LDL-c (r = 0.93) compared with the Friedewald formula (r = 0.87).
Cohort (n=10,664)
Absolute Event Rate: 0.93% vs 0.87%
BACKGROUND: Low-density lipoprotein cholesterol (LDL-c) is the major measured parameter for cardiovascular risk assessment. The generally accepted formula (LDL-F) for estimating LDL-c developed by Friedewald and colleagues in 1972 using data from 448 individuals suffers from known inaccuracies at extremes of triglyceride (TG) and total cholesterol (TC) values. METHODS: We generated new formulas based on a large Brazilian database containing directly measured lipid values from 10,664 fasted individuals. This database LDL-c was measured by the LDL-C Select FS (DiaSys) system, a homogeneous method without centrifugation. The formulas were generated using linear and non-linear approaches, and the formula with the highest accuracy and simplicity for general clinical use was selected. RESULTS: The simple formula LDL-c = 3/4 (TC - HDL-c) provided an accurate estimate of LDL-c, a higher correlation with directly measured LDL (r = 0.93) compared with LDL-F (r = 0.87), and also a higher accuracy. CONCLUSIONS: The new formula outperformed several other LDL-c formulas over a wide range of TC, HDL-c and TG values. The validation and application of this formula in other populations is warranted.
Córdova et al. (Mon,) conducted a cohort in Cardiovascular risk assessment (n=10,664). New LDL-c formula (LDL-c = 3/4 (TC - HDL-c)) vs. Friedewald formula (LDL-F) was evaluated on Correlation with directly measured LDL-c. The new simple formula LDL-c = 3/4 (TC - HDL-c) provided a higher correlation with directly measured LDL-c (r = 0.93) compared with the Friedewald formula (r = 0.87).
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