Key result
The new simple formula LDL-c = 3/4 (TC - HDL-c) provided a higher correlation with directly measured LDL-c (r = 0.93) compared with the Friedewald formula (r = 0.87).
Why the study?
Does the new formula LDL-c = 3/4 (TC - HDL-c) improve the accuracy of LDL-c estimation compared to the Friedewald formula in fasted individuals?
Population
10,664 fasted individuals from a Brazilian database
Comparison
New formula for LDL-c estimation: LDL-c = 3/4 vs Friedewald formula (LDL-F)
Design
Cohort
Authors
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May support refined LDL-c estimation in fasting samples; leaves open prospective outcome validation before practice change.
Cohort (n=10,664)
Does the new formula LDL-c = 3/4 (TC - HDL-c) improve the accuracy of LDL-c estimation compared to the Friedewald formula in fasted individuals?
Absolute Event Rate: 0.93% vs 0.87%
A new simple formula, LDL-c = 3/4 (TC - HDL-c), provides a more accurate estimation of LDL-cholesterol than the traditional Friedewald equation.
Córdova et al. (2012) conducted a cohort in Cardiovascular risk assessment (n=10,664). New LDL-c formula (LDL-c = 3/4 (TC - HDL-c)) vs. Friedewald formula (LDL-F) was evaluated on Correlation with directly measured LDL-c. The new simple formula LDL-c = 3/4 (TC - HDL-c) provided a higher correlation with directly measured LDL-c (r = 0.93) compared with the Friedewald formula (r = 0.87).
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