Navigated free-breathing 3D LGE-CMR yielded similar scar mass compared to breath-hold imaging (15.5 g vs 15.5 g, p=0.997), while high-resolution free-breathing increased scar edge sharpness.
Observational (n=48)
No
Does navigated free-breathing 3D LGE-CMR provide comparable scar mass quantification and image quality to breath-hold 3D LGE-CMR in patients with cardiomyopathy?
Navigated free-breathing 3D LGE-CMR is a reliable alternative to breath-hold imaging for myocardial scar quantification, enabling higher spatial resolution that improves scar sharpness and reduces partial volume overestimation.
Effect estimate: mean difference 0.00 g
Absolute Event Rate: 15.5% vs 15.5%
p-value: p=0.997
PURPOSE: To compare breath-hold (BH) with navigated free-breathing (FB) 3D late gadolinium enhancement cardiac MRI (LGE-CMR) MATERIALS AND METHODS: Fifty-one patients were retrospectively included (34 ischaemic cardiomyopathy, 14 non-ischaemic cardiomyopathy, three discarded). BH and FB 3D phase sensitive inversion recovery sequences were performed at 3T. FB datasets were reformatted into normal resolution (FB-NR, 1.46x1.46x10mm) and high resolution (FB-HR, isotropic 0.91-mm voxels). Scar mass, scar edge sharpness (SES), SNR and CNR were compared using paired-samples t-test, Pearson correlation and Bland-Altman analysis. RESULTS: Scar mass was similar in BH and FB-NR (mean ± SD: 15.5±18.0 g vs. 15.5±16.9 g, p=0.997), with good correlation (r=0.953), and no bias (mean difference ± SD: 0.00±5.47 g). FB-NR significantly overestimated scar mass compared with FB-HR (15.5±16.9 g vs 14.4±15.6 g; p=0.007). FB-NR and FB-HR correlated well (r=0.988), but Bland-Altman demonstrated systematic bias (1.15±2.84 g). SES was similar in BH and FB-NR (p=0.947), but significantly higher in FB-HR than FB-NR (p<0.01). SNR and CNR were lower in BH than FB-NR (p<0.01), and lower in FB-HR than FB-NR (p<0.01). CONCLUSION: Navigated free-breathing 3D LGE-CMR allows reliable scar mass quantification comparable to breath-hold. During free-breathing, spatial resolution can be increased resulting in improved sharpness and reduced scar mass. KEY POINTS: • Navigated free-breathing 3D late gadolinium enhancement is reliable for myocardial scar quantification. • High-resolution 3D late gadolinium enhancement increases scar sharpness • Ischaemic and non-ischaemic cardiomyopathy patients can be imaged using free-breathing LGE CMR.
Bizino et al. (Fri,) conducted a observational in Ischaemic and non-ischaemic cardiomyopathy (n=48). Navigated free-breathing 3D LGE-CMR vs. Breath-hold 3D LGE-CMR was evaluated on Scar mass (mean difference 0.00 g, p=0.997). Navigated free-breathing 3D LGE-CMR yielded similar scar mass compared to breath-hold imaging (15.5 g vs 15.5 g, p=0.997), while high-resolution free-breathing increased scar edge sharpness.