Is atrial fibrillation associated with an increased prevalence of myocardial and cerebral infarctions in an aged autopsy cohort?
Atrial fibrillation is strongly associated with increased rates of small myocardial infarctions and large cerebral infarctions, likely driven by embolism from mural thrombi.
Pathogenetic role of atrial fibrillation (AF) on myocardial and cerebral infarctions was studied in 2340 consecutive autopsies of the aged. AF was found in 405 cases or 17.3%, and the incidence of AF increased with age. Myocardial infarction and scar were found in 56.8% in AF, but in 36.4% in non-AF (p less than 0.001). Small myocardial infarction was 2.9 times (12.6% vs. 4.3%), and the scar was 1.5 times (27.2% vs. 18.7%) as prevalent in AF as in non-AF. Intracardiac mural thrombus was found in 14.8% in AF and in 4.8% in non-AF, 8 to 10 times as prevalent in small myocardial infarction (29.4% vs. 3.7%) and scar (17.4% vs. 1.7%) in AF as in non-AF. Coronary stenotic index revealed no difference between AF and non-AF. Large cerebral infarction was observed in 21.9% in AF and 7.3% in non-AF, and this difference was prominent in cases with myocardial infarction or myocardial scar indicating the common pathogenetic role of AF. In cases with large cerebral infarction severe cerebral atherosclerosis was less frequent in AF than in non-AF. Medium sized cortical infarction was also prevalent in AF. The prevalences of myocardial and cerebral infarctions were not different in AF complicated with valvular heart disease from those without it, but increased in the permanent AF in comparison to the transient AF. AF induced small myocardial infarction and large or medium sized cerebral infarctions by embolism from mural thrombus. The mechanism for the difference in size is discussed.
Kuramoto et al. (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: