Baroreceptor activation via phase-related external suction significantly attenuated Achilles tendon reflexes (P<0.0001) and pain perception (P<0.0001 to P=0.0006) in humans.
p-value: p=<0.0001
Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
Dworkin et al. (Tue,) conducted a other in Healthy volunteers and cardiac ischemia patients (n=147). Phase-related external suction (PRES) baroreceptor stimulation vs. Phase-reversed control condition was evaluated on Attenuation of Achilles tendon reflex and pain perception (systolic vs diastolic stimulus presentation) (p=<0.0001). Baroreceptor activation via phase-related external suction significantly attenuated Achilles tendon reflexes (P<0.0001) and pain perception (P<0.0001 to P=0.0006) in humans.