Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.
Key result
Baroreceptor activation via phase-related external suction significantly attenuated Achilles tendon reflexes (P<0.0001) and pain perception (P<0.0001 to P=0.0006) in humans.
Why the study?
Does noninvasive baroreceptor stimulation attenuate pain perception and the Achilles tendon reflex in humans?
Population
Humans
Design
Other
Authors
Discussion
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Member takes
Implication
May inform noninvasive pain modulation; leaves open therapeutic role in hypertension pending larger trials.
Structured PICO
Does noninvasive baroreceptor stimulation attenuate pain perception and the Achilles tendon reflex in humans?
P
Population
Humans
I
Intervention
Noninvasive behaviorally unbiased method for baroreceptor stimulation
O
Outcome
Attenuation of pain perception and of the Achilles tendon reflexsurrogate
Main Result
p-value: p=<0.0001
Noninvasive baroreceptor stimulation in humans attenuates pain perception and the Achilles tendon reflex, which may have implications for blood pressure regulation and hypertension pathophysiology.
Limitations
- Technical limitation from the approximately rectangular shape of the neck-chamber suction and pressure waveforms, which distorts the resultant waveform and only partially cancels the intraarterial wave in the control condition.
Cite This Study
Dworkin et al. (1994) studied Healthy volunteers and cardiac ischemia patients (n=147). Phase-related external suction (PRES) baroreceptor stimulation vs. Phase-reversed control condition was evaluated on Attenuation of Achilles tendon reflex and pain perception (systolic vs diastolic stimulus presentation) (p=<0.0001). Baroreceptor activation via phase-related external suction significantly attenuated Achilles tendon reflexes (P<0.0001) and pain perception (P<0.0001 to P=0.0006) in humans.