The combination of lisinopril and physical training increased exercise time from 13.6 min with placebo to 16.1 min, providing the most significant improvements in cardiorespiratory fitness.
RCT (n=12)
Placebo-controlled
Crossover
Absolute Event Rate: 16.1% vs 13.6%
A total of 12 patients (mean age +/- SEM 63 +/- 2.6 years) with moderate to severe heart failure (ejection fraction = 23 +/- 3.2%) were included in a placebo-controlled crossover trial. Patients were randomly allocated to 4 periods of 6 weeks each: placebo, placebo and physical training, lisinopril 10 mg daily, and lisinopril and physical training. The exercise time increased from 13.6 +/- 0.9 min with placebo to 15 +/- 1 min with training alone, and to 16.1 +/- 0.7 min with lisinopril and training. With lisinopril alone there was a non-significant increase in exercise time, to 14.5 +/- 0.6 min. Improvements in exercise time were accompanied by a similar increase in peak oxygen consumption. Overall, the most significant improvements in symptoms and indices of cardiorespiratory fitness were achieved with a combination of lisinopril and training. Thus physical training is not only a useful adjunct to the existing medical therapy for heart failure, but it may also provide symptomatic benefits in its own right.
Meyer et al. (Fri,) conducted a rct in Moderate to severe heart failure (n=12). Lisinopril and physical training vs. Placebo was evaluated on Exercise time (min). The combination of lisinopril and physical training increased exercise time from 13.6 min with placebo to 16.1 min, providing the most significant improvements in cardiorespiratory fitness.
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