November 1, 1991Journal of Internal Medicine
Angiotensin‐converting enzyme inhibition and physical training in heart failure
Key result
The combination of lisinopril and physical training increased exercise time from 13.6 min with placebo to 16.1 min, providing the most significant improvements in cardiorespiratory fitness.
Why the study?
Does lisinopril, physical training, or their combination improve exercise capacity and symptoms in patients with moderate to severe heart failure?
Population
12 patients with moderate to severe heart failure, mean age 63 +/- 2.6 years.
Comparison
Lisinopril 10 mg daily, physical training, or… vs Placebo.
Design
RCT, Randomly allocated to 4 periods of 6 weeks each, Placebo-controlled
Follow-up
4 periods of 6 weeks each (24 weeks total)
Authors
Discussion
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Implication
Combination of lisinopril and exercise training maximizes exercise capacity gains in moderate-severe HF; extends ACE inhibitor benefits via additive training effects.
Study Design
Type
RCT (n=12)
Blinding
Placebo-controlled
Randomization
Crossover
Structured PICO
Does lisinopril, physical training, or their combination improve exercise capacity and symptoms in patients with moderate to severe heart failure?
P
Population
12 patients with moderate to severe heart failure (ejection fraction = 23 +/- 3.2%), mean age 63 +/- 2.6 years.
I
Intervention
Lisinopril 10 mg daily, physical training, or their combination, administered in 6-week periods.
C
Comparator
Placebo (crossover design where patients served as their own controls across 4 periods).
O
Outcome
Exercise time.surrogate
Main Result
Absolute Event Rate: 16.1% vs 13.6%
The combination of lisinopril and physical training provides the most significant improvements in exercise capacity and symptoms for patients with moderate to severe heart failure.
Cite This Study
Meyer et al. (1991) conducted an RCT in Moderate to severe heart failure (n=12). Lisinopril and physical training vs. Placebo was evaluated on Exercise time (min). The combination of lisinopril and physical training increased exercise time from 13.6 min with placebo to 16.1 min, providing the most significant improvements in cardiorespiratory fitness.