Key result
Combining exercise training with lisinopril in spontaneously hypertensive rats increased fractional shortening by 25% and improved diastolic function markers more than either intervention alone.
Why the study?
Does the combination of exercise training and lisinopril improve left ventricular function in spontaneously hypertensive rats compared to either intervention alone or sedentary controls?
Does the combination of exercise training and lisinopril improve left ventricular function in spontaneously hypertensive rats compared to either intervention alone or sedentary controls?
The combination of lisinopril and moderate exercise training provides additive benefits in attenuating cardiac dysfunction in a genetic model of hypertension.
Supports further study of combined exercise and lisinopril for LV function in hypertension; does not yet inform clinical practice.
OBJECTIVES: To investigate whether the combination of exercise training with the angiotensin-converting enzyme inhibitor lisinopril will have an additional beneficial effect on left ventricular function in spontaneously hypertensive rats. DESIGN: Twelve-week-old male rats were assigned to treadmill running (Ht-Ex; 20 m/min at 5 degrees grade, 1 h/day, 5 days/week), or lisinopril treatment (Ht-Lis; 15 mg/kg per day by gavage), or treadmill running while treated with lisinopril (Ht-ExLis), and were compared with a sedentary group (Ht-Sed). Age-matched and sex-matched Wistar-Kyoto rats were controls. METHODS: After 10 weeks of experimentation, left ventricular morphology and function were assessed from M-mode echocardiograms and transmitral Doppler spectra [early (E) and atrial peak velocities (A), their ratio (E/A), and E-wave deceleration time (Edec time) and slope (Edec slope)]. RESULTS: Ht-Sed exhibited prominent concentric left ventricular hypertrophy with systolic and diastolic dysfunctions evidenced by a significantly reduced fractional shortening (%FS) and 'pseudonormalization' of left ventricular filling, characterized by an apparently normal E/A ratio despite an underlying left ventricular relaxation abnormality. Exercise training did not significantly alter left ventricular morphology or function. Lisinopril alone attenuated left ventricular hypertrophy and enhanced diastolic function but had no significant effect on systolic function. Combining exercise training with lisinopril treatment increased %FS by 25%, decreased the E/A ratio and Edec slope by 35% and 37%, respectively, and increased Edec time by 82%. CONCLUSION: Our results provide experimental evidence that lisinopril administration, when combined with moderate exercise training, is more promising in attenuating cardiac dysfunction than either agent alone in hypertension of a genetic origin.
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Amal Ziada (2009) studied Hypertension. Exercise training combined with lisinopril vs. Sedentary, exercise alone, lisinopril alone, and normotensive controls was evaluated on Left ventricular morphology and function. Combining exercise training with lisinopril in spontaneously hypertensive rats increased fractional shortening by 25% and improved diastolic function markers more than either intervention alone.
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