Glucose levels during sleep demonstrated a moderate negative correlation with heart rate variability (r = -0.453), indicating glucose fluctuations may reflect autonomic nervous system activity.
Cross-Sectional (n=5)
Do glucose fluctuations correlate with heart rate variability during sleep in healthy subjects?
Glucose fluctuations during sleep show a moderate negative correlation with heart rate variability, suggesting potential utility as a marker of autonomic nervous system activity.
Effect estimate: r = -0.453
OBJECTIVE: The body's glucose concentration is influenced by carbohydrate intake, insulin-induced carbohydrate reduction, and hepatic glycogen breakdown induced by stress hormones. This study investigated the potential of employing glucose fluctuations as a measure of stress by examining the relationship between heart rate variability (HRV) data and glucose levels during sleep in healthy subjects. METHODS: In this cross-sectional study, a chest-worn electrocardiogram (ECG) and continuous glucose monitoring device (CGM) were respectively used to monitor the heart rate intervals and glucose fluctuations of five subjects (two males, three females) during sleep. A time-series correlation analysis was performed on the HRV data extracted from heart rate intervals and the corresponding glucose fluctuation data. RESULTS: The time-series analysis of ECG and CGM data collected from subjects during sleep (n = 25 nights) revealed a moderate negative correlation between glucose levels and HRV, with a cross-correlation coefficient of r = -0.453. CONCLUSION: Similar to HRV, changes in stress levels can be detected by observing glucose fluctuations, particularly during sleep when the impact of food intake can be eliminated. Our findings highlight a significant correlation between glucose levels and HRV, indicating that glucose fluctuations can be used as an indicator of autonomic nervous system activity in an exploratory study.
Kajisa et al. (Tue,) conducted a cross-sectional in Healthy subjects (n=5). Continuous glucose monitoring and electrocardiogram was evaluated on Correlation between glucose levels and heart rate variability (r = -0.453). Glucose levels during sleep demonstrated a moderate negative correlation with heart rate variability (r = -0.453), indicating glucose fluctuations may reflect autonomic nervous system activity.