Co-administration of Quercetin and NLRP3 Inhibitor Attenuates Inflammation and Oxidative Stress in Cuprizone-Induced Demyelination Model

Key Points

• The study aims to assess the effectiveness of quercetin and MCC950 in reducing demyelination and inflammation.
• In vivo model of demyelination induced by cuprizone was utilized.
• Intervention involved co-administration of quercetin and NLRP3 inhibitor MCC950.
• Assessment of inflammation and oxidative stress levels in the corpus callosum was performed.
• Co-administration of quercetin and MCC950 significantly ameliorated demyelination in the corpus callosum.
• Marked reduction in astrocytes activation was observed with treatment.
• Oxidative stress and inflammation levels were significantly lower in the treated group.