Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

Key Points

• To explore a metal-free method for the synthesis of masked α, β-unsaturated trifluoromethyl ketones.
• Utilized iodine(III) for decarboxylative trifluoroacetylation
• Employed PhI(OCOMe)₂ as a reagent
• Focused on masked α, β-unsaturated carboxylic acids and cyclic CF₃-pyruvate acetals.
• Successfully synthesized trifluoromethyl ketones from masked α, β-unsaturated carboxylic acids.
• Demonstrated the efficiency of the metal-free protocol.
• Available data indicate high reaction yields.