Does high-dose cisapride cause acquired QT prolongation and ventricular arrhythmias?
High-dose cisapride is associated with acquired long QT syndrome and potentially life-threatening ventricular arrhythmias.
The gastrointestinal prokinetic drug, cisapride, is widely used for the treatment of diabetic gastroparesis and disorders of gastrointestinal motility. We present a case of acquired QT prolongation, syncope, and nonsustained ventricular tachycardia associated with high doses of cisapride.
Sergio Bran (Mon,) studied this question.