Why the study?
Does high-dose cisapride cause acquired QT prolongation and ventricular arrhythmias?
Does high-dose cisapride cause acquired QT prolongation and ventricular arrhythmias?
High-dose cisapride is associated with acquired long QT syndrome and potentially life-threatening ventricular arrhythmias.
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High-dose cisapride may cause QT prolongation and arrhythmias; this single case leaves open causality and population risk.
The gastrointestinal prokinetic drug, cisapride, is widely used for the treatment of diabetic gastroparesis and disorders of gastrointestinal motility. We present a case of acquired QT prolongation, syncope, and nonsustained ventricular tachycardia associated with high doses of cisapride.
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Sergio Bran (1995) studied this question.
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