Why the study?
Does cisapride prolong the QTc interval in pediatric patients with gastroesophageal reflux?
Population
49 children between 6 months and 4 years of age with symptoms of gastroesophageal reflux not responding to…
Comparison
Cisapride 0.2 mg/kg three times daily for 3 to 8… vs Placebo
Design
RCT, Randomized to receive active drug or placebo, Double-blind; ECGs reviewed…
Follow-up
3 to 8 weeks
Authors
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Reassures clinicians on QTc safety for cisapride in pediatric GER without cardiac disease; confirms no prolongation in this RCT.
Does cisapride prolong the QTc interval in pediatric patients with gastroesophageal reflux?
Cisapride does not significantly prolong the QTc interval in pediatric patients without underlying cardiac disease or electrolyte imbalance.
Levy et al. (2001) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: