Why the study?
Does concurrent use of cisapride and CYP3A4 inhibitors increase the risk of cardiac arrhythmias in pediatric patients?
Population
Pediatric patients with gastroesophageal reflux or other motor disorders of the gastrointestinal tract
Design
Review
Authors
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May warrant avoiding cisapride with CYP3A4 inhibitors in children; leaves open need for prospective pediatric safety data.
Does concurrent use of cisapride and CYP3A4 inhibitors increase the risk of cardiac arrhythmias in pediatric patients?
Cisapride should be used with extreme caution, if at all, in combination with macrolides or azole antifungals due to the risk of potentially fatal cardiac arrhythmias.
Robert J. Shulman (1996) studied this question.
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