Why the study?
Does cisapride prolong ventricular repolarization in children with GERD?
Population
35 children with gastroesophageal reflux disease taking cisapride, and a control group of 1000 normal…
Comparison
Cisapride vs 1000 normal children
Design
Cohort, blinded
Authors
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Alerts clinicians to QTc risk with cisapride plus macrolides in children; leaves open causality and need for prospective trials.
Does cisapride prolong ventricular repolarization in children with GERD?
Cisapride use in children is associated with prolonged ventricular repolarization and risk of torsades de pointes, especially when combined with CYP3A4 inhibitors like macrolides.
Hill et al. (1998) studied this question.
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