Spontaneous Adverse Event Reports of Serious Ventricular Arrhythmias, QT Prolongation, Syncope, and Sudden Death in Patients Treated with Cisapride
Why the study?
Are recognized risk factors present in cases of cisapride-associated long QT syndrome?
Population
574 reported cases of adverse cardiac events in patients treated with cisapride as of October 1999
Design
Case_series
Authors
Discussion
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Member takes
Implication
Cofactors present in most cisapride-associated QT cases; leaves open whether avoidance reduces risk.
Structured PICO
Are recognized risk factors present in cases of cisapride-associated long QT syndrome?
P
Population
574 reported cases of adverse cardiac events (serious ventricular arrhythmias, QT prolongation, syncope, and sudden death) in patients treated with cisapride as of October 1999
I
Intervention
Cisapride
O
Outcome
Confirmed cases of long QT syndrome or isolated QT prolongation and the presence of recognized risk factors (cofactors)safety
Most cases of cisapride-associated long QT syndrome occur in the presence of recognized risk factors, suggesting that the risk can be minimized by avoiding these cofactors.
Cite This Study
Barbey et al. (2002) studied this question.