G Proteins: Transducers Of Receptor-Generated Signals

PERSPECTIVES AND SUMMARy ......... .. ........ . ...... 615 HISTORy ....... ...... . . . . . ...... . . .. .... . . . .. . 616 INDIVIDUAL G PROTEINS: FUNCTIONS AND MOLECULAR ENTITIES 617 Criter ia for In volvemen t o f a G Pr otein ..... ......... 618 Func ti on s R egu la ted b y G Protein s ... . .... . ... . . . .. .. 619 M olecu lar En tities and S truc ture . . . . . . . ... . . . . . . .... . . . . . . ..... . . . . . . . .. . . . . . . .. . . . .. . . . .. . . . . 622 LIGAND--G PROTEIN INTERACTIONS 63 1 LIGAND-REGULATED PROTEIN-PROTEIN INTERACTIONS 634 Receptor-O Protein J nteractions. . .. .. . . . . . . . . .. . . .. . . . . . . .. . ........ . ..... . ... . ...... . . . . . . . . . 634 G Pr otein -Effec tor In teraction s . . . . ....... . . . .. .. ... . . . . . . . ... . .... . .. . . . ...... . .. ....... .... . . 638 G PROTEIN-MEMBRANE INTERACTIONS 643 COVALENT MODIFICATION OF G PROTEINS 644