Metal‐Free Synthesis of 3‐Trifluoromethyl‐1,2,4‐triazoles via 4+1 Cyclization of Trifluoroacetimidohydrazides With BrCF 2 COOEt as a C1 Synthon

Key Points

• This research aims to develop a metal-free method for synthesizing 3-trifluoromethyl-1,2,4-triazoles through cyclization techniques.
• Utilized trifluoroacetimidohydrazides and BrCF2COOEt as reactants.
• Employed a [4+1] cyclization reaction without metal catalysts.
• Generated difluorocarbene in situ during the transformation.
• Successfully synthesized 3-trifluoromethyl-1,2,4-triazoles through the proposed method.
• BrCF2COOEt successfully acted as a C1 synthon in the reaction mechanism.