Demonstrates metal-free synthesis of 3-trifluoromethyl-1,2,4-triazoles, indicating a new chemical pathway.
A metal‐free [4+1] cyclization of trifluoroacetimidohydrazides with BrCF 2 COOEt for the synthesis of 3‐trifluoromethyl‐1,2,4‐triazoles has been achieved. In the transformation, BrCF 2 COOEt acts as a C1 synthon and a precursor of difluorocarbene via quadruple cleavage. Difluorocarbene is regarded as in situ generated and participates in the reaction.
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Zhang et al. (2026) studied this question.
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